Elevated depressive symptoms and incident stroke in Hispanic, African-American, and White older Americans.

TitleElevated depressive symptoms and incident stroke in Hispanic, African-American, and White older Americans.
Publication TypeJournal Article
Year of Publication2012
AuthorsM. Glymour, M, Yen, JJ, Kosheleva, A, J Moon, R, Capistrant, BD, Patton, KK
JournalJournal of Behavioral Medicine
ISSN Number1573-3521
KeywordsAfrican Americans, Age Factors, Aged, depression, European Continental Ancestry Group, Female, Health Surveys, Hispanic Americans, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Prevalence, Risk Factors, Stroke, United States

Although depressive symptoms have been linked to stroke, most research has been in relatively ethnically homogeneous, predominantly white, samples. Using the United States based Health and Retirement Study, we compared the relationships between elevated depressive symptoms and incident first stroke for Hispanic, black, or white/other participants (N = 18,648) and estimated the corresponding Population Attributable Fractions. The prevalence of elevated depressive symptoms was higher in blacks (27%) and Hispanics (33%) than whites/others (18%). Elevated depressive symptoms prospectively predicted stroke risk in the whites/other group (HR = 1.53; 95% CI: 1.36-1.73) and among blacks (HR = 1.31; 95% CI: 1.05-1.65). The HR was similar but only marginally statistically significant among Hispanics (HR = 1.33; 95% CI: 0.92-1.91). The Population Attributable Fraction, indicating the percent of first strokes that would be prevented if the incident stroke rate in those with elevated depressive symptoms was the same as the rate for those without depressive symptoms, was 8.3% for whites/others, 7.8% for blacks, and 10.3% for Hispanics.

Endnote Keywords

depression/stroke/African American/Hispanics/Population Attributable Fraction/Population Attributable Fraction

Endnote ID


Citation Key7690
PubMed ID21656258
PubMed Central IDPMC3305882
Grant ListT32 HL098048 / HL / NHLBI NIH HHS / United States
T32-HL098048-01 / HL / NHLBI NIH HHS / United States