Chemotherapy was not associated with cognitive decline in older adults with breast and colorectal cancer: findings from a prospective cohort study.

TitleChemotherapy was not associated with cognitive decline in older adults with breast and colorectal cancer: findings from a prospective cohort study.
Publication TypeJournal Article
Year of Publication2012
AuthorsShaffer, VA, Merkle, EC, Fagerlin, A, Griggs, JJ, Langa, KM, Iwashyna, TJ
JournalMed Care
Volume50
Issue10
Pagination849-55
Date Published2012 Oct
ISSN Number1537-1948
KeywordsAge Factors, Aged, Aged, 80 and over, Aging, Antineoplastic Agents, Antineoplastic Protocols, Bayes Theorem, Breast Neoplasms, Cognition Disorders, Colorectal Neoplasms, Female, Health Behavior, Humans, Interviews as Topic, Male, Memory, Prospective Studies
Abstract

OBJECTIVES: This study tested 2 hypotheses: (1) chemotherapy increases the rate of cognitive decline in breast and colorectal cancer patients beyond what is typical of normal aging and (2) chemotherapy results in systematic cognitive declines when compared with breast and colorectal cancer patients who did not receive chemotherapy.

SUBJECTS: Data came from personal interviews with a prospective cohort of patients with breast (n=141) or colorectal cancer (n=224) with incident disease drawn from the nationally representative Health and Retirement Study (1998-2006) with linked Medicare claims.

MEASURES: The 27-point modified Telephone Interview for Cognitive Status was used to assess cognitive functioning, focusing on memory and attention. We defined the smallest clinically significant change as 0.4 points per year.

RESULTS: We used Bayesian hierarchical linear models to test the hypotheses, adjusting for multiple possible confounders. Eighty-eight patients were treated with chemotherapy; 277 were not. The mean age at diagnosis was 75.5. Patients were followed for a median of 3.1 years after diagnosis, with a range of 0 to 8.3 years. We found no differences in the rates of cognitive decline before and after diagnosis for patients who received chemotherapy in adjusted models (P=0.86, one-sided 95% posterior intervals lower bound: 0.09 worse after chemotherapy), where patients served as their own controls. Moreover, the rate of cognitive decline after diagnosis did not differ between patients who had chemotherapy and those who did not (P=0.84, one-sided 95% posterior intervals lower bound: 0.11 worse for chemotherapy group in adjusted model).

CONCLUSIONS: There was no evidence of cognitive decline associated with chemotherapy in this sample of older adults with breast and colorectal cancer.

Notes

Med Care. 2012 Jun 6.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/22683591
DOI10.1097/MLR.0b013e31825a8bb0
User Guide Notes

http://www.ncbi.nlm.nih.gov/pubmed/22683591?dopt=Abstract

Endnote Keywords

chemotherapy/Cognitive decline/CANCER/Medicare claims/Linear Models/Linear Models

Endnote ID

69448

Alternate JournalMed Care
Citation Key7708
PubMed ID22683591
PubMed Central IDPMC3444668
Grant ListU01 AG009740 / AG / NIA NIH HHS / United States
R01 AG030155 / AG / NIA NIH HHS / United States
UL1RR024986 / RR / NCRR NIH HHS / United States
U01 AG09740 / AG / NIA NIH HHS / United States
R01 AG027010 / AG / NIA NIH HHS / United States
K08 HL091249 / HL / NHLBI NIH HHS / United States
UL1 RR024986 / RR / NCRR NIH HHS / United States