Title | Five-factor model personality traits and inflammatory markers: new data and a meta-analysis. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Luchetti, M, Barkley, JM, Stephan, Y, Terracciano, A, Sutin, AR |
Journal | Psychoneuroendocrinology |
Volume | 50 |
Pagination | 181-93 |
Date Published | 2014 Dec |
ISSN Number | 1873-3360 |
Keywords | Adult, Aged, Aged, 80 and over, Biomarkers, C-reactive protein, Female, Humans, Inflammation, Male, Middle Aged, Personality |
Abstract | The purpose of this research is to examine the association between five major dimensions of personality and systemic inflammation through (a) new data on C-reactive protein (CRP) from three large national samples of adults that together cover most of the adult lifespan and (b) a meta-analysis of published studies on CRP and interleukin-6 (IL-6). New data (total N=26,305) were drawn from the National Longitudinal Study of Adolescent Health, the Midlife in the United States study, and the Health and Retirement Study. PRISMA guidelines were used for the meta-analysis to combine results of up to seven studies on CRP (N=34,067) and six on IL-6 (N=7538). Across the three new samples, higher conscientiousness was associated with lower CRP. The conscientiousness-CRP relation was virtually identical controlling for smoking; controlling for body mass index attenuated this association but did not eliminate it. Compared to participants in the highest quartile of conscientiousness, participants in the lowest quartile had an up to 50% increased risk of CRP levels that exceeded the clinical threshold (≥3 mg/l). The meta-analysis supported the association between conscientiousness and both CRP and IL-6 and also suggested a negative association between openness and CRP; no associations were found for neuroticism, extraversion and agreeableness. The present work indicates a modest, but consistent, association between conscientiousness and a more favorable inflammatory profile, which may contribute to the role of conscientiousness in better health across the lifespan. |
Notes | Times Cited: 0 0 |
DOI | 10.1016/j.psyneuen.2014.08.014 |
User Guide Notes | |
Endnote Keywords | Personality/Personality/Conscientiousness/Conscientiousness/C-reactive protein/Interleukin-6/Meta-analysis |
Endnote ID | 999999 |
Alternate Journal | Psychoneuroendocrinology |
Citation Key | 7971 |
PubMed ID | 25233337 |
PubMed Central ID | PMC4544833 |
Grant List | UL1 TR000427 / TR / NCATS NIH HHS / United States U01 AG009740 / AG / NIA NIH HHS / United States M01 RR000865 / RR / NCRR NIH HHS / United States UL1TR000427 / TR / NCATS NIH HHS / United States U01AG009740 / AG / NIA NIH HHS / United States M01-RR00865 / RR / NCRR NIH HHS / United States P01-HD31921 / HD / NICHD NIH HHS / United States M01-RR023942 / RR / NCRR NIH HHS / United States P01-AG020166 / AG / NIA NIH HHS / United States P01 HD031921 / HD / NICHD NIH HHS / United States M01 RR023942 / RR / NCRR NIH HHS / United States P01 AG020166 / AG / NIA NIH HHS / United States |