Five-factor model personality traits and inflammatory markers: New data and a meta-analysis

TitleFive-factor model personality traits and inflammatory markers: New data and a meta-analysis
Publication TypeJournal Article
Year of Publication2014
AuthorsLuchetti, M, Barkley, JM, Stephan, Y, Terracciano, A, Sutin, AR
KeywordsHealth Conditions and Status, Methodology

The purpose of this research is to examine the association between five major dimensions of personality and systemic inflammation through (a) new data on C-reactive protein (CRP) from three large national samples of adults that together cover most of the adult lifespan and (b) a meta-analysis of published studies on CRP and interleukin-6 (IL-6). New data (total N=26,305) were drawn from the National Longitudinal Study of Adolescent Health, the Midlife in the United States study, and the Health and Retirement Study. PRISMA guidelines were used for the meta-analysis to combine results of up to seven studies on CRP (N=34,067) and six on IL-6 (N=7538). Across the three new samples, higher conscientiousness was associated with Lower CRP. The conscientiousness-CRP relation was virtually identical controlling for smoking; controlling for body mass index attenuated this association but did not eliminate it. Compared to participants in the highest quartile of conscientiousness, participants in the lowest quartile had an up to 50 increased risk of CRP levels that exceeded the clinical threshold ( = 3mg/l). The


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Endnote Keywords

Personality/Personality/Conscientiousness/Conscientiousness/C-reactive protein/Interleukin-6/Meta-analysis

Endnote ID


Citation Key7971
PubMed ID25233337
PubMed Central IDPMC4544833