Changes in Memory before and after Stroke Differ by Age and Sex, but Not by Race

TitleChanges in Memory before and after Stroke Differ by Age and Sex, but Not by Race
Publication TypeJournal Article
Year of Publication2014
AuthorsWang, Q, Mejía-Guevara, I, Rist, PM, Walter, S, Capistrant, BD, Glymour, MM
JournalCerebrovascular Diseases
Volume37
Issue4
Pagination235-243
KeywordsHealth Conditions and Status, Methodology
Abstract

Background: Post-stroke memory impairment is more common among older adults, women and blacks. It is unclear whether post-stroke differences reflect differential effects of stroke per se or differences in prestroke functioning. We compare memory trajectories before and after stroke by age, sex and race. Methods: Health and Retirement Study participants aged 50 years (n = 17,341), with no stroke history at baseline, were interviewed biennially up to 10 years for first self- or proxy-reported stroke (n = 1,574). Segmented linear regression models were used to compare annual rates of memory change before and after stroke among 1,169 stroke survivors, 405 stroke decedents and 15,767 stroke-free participants. Effect modification was evaluated with analyses stratified by baseline age ( 70 vs. 70), sex and race (white vs. nonwhite), and using interaction terms between age/sex/race indicators and annual memory change. Results: Older ( 70 years) adults experienced a faster memory decline before stroke (-0.19 vs. -0.10 points/year for survivors, -0.24 vs. -0.13 points/year for decedents, p 0.001 for both interactions), and among stroke survivors, larger memory decrements (-0.64 vs. -0.26 points, p 0.001) at stroke and faster memory decline (-0.15 vs. -0.07 points/year, p = 0.003) after stroke onset, compared to younger adults. Female stroke survivors experienced a faster prestroke memory decline than male stroke survivors (-0.14 vs. -0.10 points/year, p 0.001). However, no sex differences were seen for other contrasts. Although whites had higher post-stroke memory scores than nonwhites, race was not associated with rate of memory decline during any period of time; i.e. race did not significantly modify the rate of decline before or after stroke or the immediate effect of stroke on memory. Conclusions: Older age predicted worse memory change before, at and after stroke onset. Sex and race differences in post-stroke memory outcomes might be attributable to prestroke disparities, which may be unrelated to cerebrovascular disease. 2014 S. Karger AG, Basel.

Notes

Export Date: 21 April 2014 Source: Scopus Article in Press

URLhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84897121425andpartnerID=40andmd5=22785f81bf8b09c85697670c6a2e2382
Endnote Keywords

Memory change/Stroke/Effect modifier

Endnote ID

999999

Citation Key8052