Title | A polygenic risk score associated with measures of depressive symptoms among older adults. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Levine, ME, Crimmins, EM, Prescott, CA, Phillips, DF, Arpawong, TE, Lee, J |
Journal | Biodemography Soc Biol |
Volume | 60 |
Issue | 2 |
Pagination | 199-211 |
Date Published | 2014 |
ISSN Number | 1948-5573 |
Keywords | Aged, Aged, 80 and over, Depressive Disorder, Major, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Male, Middle Aged, Multifactorial Inheritance, Odds Ratio, Risk Factors |
Abstract | It has been suggested that depression is a polygenic trait, arising from the influences of multiple loci with small individual effects. The aim of this study is to generate a polygenic risk score (PRS) to examine the association between genetic variation and depressive symptoms. Our analytic sample included N = 10,091 participants aged 50 and older from the Health and Retirement Study (HRS). Depressive symptoms were measured by Center for Epidemiological Studies-Depression scale (CESD) scores assessed on up to nine occasions across 18 years. We conducted a genome-wide association analysis for a discovery set (n = 7,000) and used the top 11 single-nucleotide polymorphisms, all with p < 10(-5) to generate a weighted PRS for our replication sample (n = 3,091). Results showed that the PRS was significantly associated with mean CESD score in the replication sample (β = .08, p = .002). The R(2) change for the inclusion of the PRS was .003. Using a multinomial logistic regression model, we also examined the association between genetic risk and chronicity of high (4+) CESD scores. We found that a one-standard-deviation increase in PRS was associated with a 36 percent increase in the odds of having chronically high CESD scores relative to never having had high CESD scores. Our findings are consistent with depression being a polygenic trait and suggest that the cumulative influence of multiple variants increases an individual's susceptibility for chronically experiencing high levels of depressive symptoms. |
Notes | Times Cited: 0 SI 0 |
DOI | 10.1080/19485565.2014.952705 |
User Guide Notes | |
Endnote Keywords | GENOME-WIDE ASSOCIATION/INDIVIDUAL GENETIC RISK/MAJOR DEPRESSION/DISEASE RISK/HERITABILITY/genetics/genetics/depression/Depressive Symptoms/CES Depression Scale/CES Depression Scale/regression Analysis |
Endnote ID | 999999 |
Alternate Journal | Biodemography Soc Biol |
Citation Key | 8057 |
PubMed ID | 25343367 |
PubMed Central ID | PMC4298361 |
Grant List | U01 AG009740 / AG / NIA NIH HHS / United States T32 AG000037 / AG / NIA NIH HHS / United States F32AG048681 / AG / NIA NIH HHS / United States P30AG017265 / AG / NIA NIH HHS / United States R01 AG030153 / AG / NIA NIH HHS / United States T32AG0037 / AG / NIA NIH HHS / United States P30 AG017265 / AG / NIA NIH HHS / United States R01AG030153 / AG / NIA NIH HHS / United States F32 AG048681 / AG / NIA NIH HHS / United States |