|Title||Multimorbidity redefined: prospective health outcomes and the cumulative effect of co-occurring conditions.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Koroukian, SM, Warner, DF, Owusu, C, Given, CW|
|Journal||Prev Chronic Dis|
|Date Published||2015 Apr 23|
|Keywords||Aged, Aged, 80 and over, Alcohol Drinking, Body Mass Index, Chronic disease, Cognition Disorders, Comorbidity, Cross-Sectional Studies, Data Interpretation, Statistical, Ethnic Groups, Female, Health Status Indicators, Humans, Interviews as Topic, Male, Middle Aged, Mobility Limitation, Outcome Assessment, Health Care, Prospective Studies, Recurrence, Retirement, Self Report, Smoking, Social Class, Syndrome, United States, Vulnerable Populations|
INTRODUCTION: Multimorbidity is common among middle-aged and older adults; however the prospective effects of multimorbidity on health outcomes (health status, major health decline, and mortality) have not been fully explored. This study addresses this gap in the literature.
METHODS: We used self-reported data from the 2008 and 2010 Health and Retirement Study. Our study population included 13,232 adults aged 50 or older. Our measure of baseline multimorbidity in 2008 was based on the occurrence or co-occurrence of chronic conditions, functional limitations, and/or geriatric syndromes, as follows: MM0, no chronic conditions, functional limitations, or geriatric syndromes; MM1, occurrence (but no co-occurrence) of chronic conditions, functional limitations, or geriatric syndromes; MM2, co-occurrence of any 2 of chronic conditions, functional limitations, or geriatric syndromes; and MM3, co-occurrence of all 3 of chronic conditions, functional limitations, and geriatric syndromes. Outcomes in 2010 included fair or poor health status, major health decline, and mortality.
RESULTS: All 3 outcomes were significantly associated with multimorbidity. Compared with MM0 (respectively for fair or poor health and major health decline), the adjusted odds ratios (AORs) and 95% confidence intervals were as follows: 2.61 (1.79-3.78) and 2.20 (1.42-3.41) for MM1; 7.49 (5.20-10.77) and 3.70 (2.40-5.71) for MM2; and 22.66 (15.64-32.83) and 4.72 (3.03-7.37) for MM3. Multimorbidity was also associated with mortality: an adult classified as MM3 was nearly 12 times (AOR, 11.87 [5.72-24.62]) as likely as an adult classified as MM0 to die within 2 years.
CONCLUSION: Given the strong and significant association between multimorbidity and prospective health status, major health decline, and mortality, multimorbidity may be used - both in clinical practice and in research - to identify older adults with heightened vulnerability for adverse outcomes.
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|User Guide Notes|
|Endnote Keywords|| |
MORBIDITY/health status/health decline/mortality/baseline multimorbidity/health status
|Endnote ID|| |
|Alternate Journal||Prev Chronic Dis|
|PubMed Central ID||PMC4415428|
|Grant List||R21 HS023113 / HS / AHRQ HHS / United States |
UL1 RR024989 / RR / NCRR NIH HHS / United States
UL1 TR000439 / TR / NCATS NIH HHS / United States
UL1RR024989 / RR / NCRR NIH HHS / United States
R21 HS023113-01 / HS / AHRQ HHS / United States