Depressive symptoms, psychiatric medication use, and risk of type 2 diabetes: results from the Health and Retirement Study

TitleDepressive symptoms, psychiatric medication use, and risk of type 2 diabetes: results from the Health and Retirement Study
Publication TypeJournal Article
Year of Publication2015
AuthorsRatliff, S, Mezuk, B
JournalGeneral Hospital Psychiatry
Volume37
Issue5
Pagination420-426
KeywordsHealth Conditions and Status, Healthcare, Methodology
Abstract

AbstractObjective This prospective study investigates the relationships between depressive symptoms, psychiatric medication use, and their interaction on risk of developing type 2 diabetes. Method Data come from the 1998 2010 waves of the Health and Retirement Study, a US nationally representative cohort of adults aged 51 years and older. Analysis is restricted to participants andlt; 65 years old who did not have diabetes in 1998 (N= 8704). Depressive symptoms were assessed using the 8-item Center for Epidemiologic Studies Depression Scale. Risk of diabetes over the 12-year follow-up period was assessed using Cox proportional hazard models with time-varying covariates. Results After adjusting for covariates, both depressive symptoms hazard ratio (HR): 1.06, 95 confidence interval (CI): 1.02 1.09 and psychiatric medication use (HR: 1.57, 95 CI: 1.25 1.96) were associated with development of diabetes. The interaction between depressive symptoms and medication use was significant (beta= 0.240, P= .049), indicating that the association between elevated depressive symptoms and diabetes was higher among respondents not taking medications. The associations between depressive symptoms and medication use were also attenuated by increasing body mass index. Conclusion Findings highlight the complex relationship between depressive symptoms and psychiatric medications on diabetes risk and the need for a nuanced understanding of these factors.

URLhttp://www.sciencedirect.com/science/article/pii/S0163834315001334
DOI10.1016/j.genhosppsych.2015.05.008
Endnote Keywords

Depression/Antidepressants/Type 2 diabetes/Longitudinal/Epidemiology

Endnote ID

999999

Citation Key8207
PubMed ID26094130
PubMed Central IDPMC4558325