|Title||Depressive symptoms, psychiatric medication use, and risk of type 2 diabetes: results from the Health and Retirement Study.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Ratliff, SM, Mezuk, B|
|Journal||Gen Hosp Psychiatry|
|Date Published||2015 Sep-Oct|
|Keywords||Antidepressive Agents, Cohort Studies, depression, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Risk Assessment, Surveys and Questionnaires|
OBJECTIVE: This prospective study investigates the relationships between depressive symptoms, psychiatric medication use, and their interaction on risk of developing type 2 diabetes.
METHOD: Data come from the 1998-2010 waves of the Health and Retirement Study, a US nationally representative cohort of adults aged 51 years and older. Analysis is restricted to participants <65 years old who did not have diabetes in 1998 (N=8704). Depressive symptoms were assessed using the 8-item Center for Epidemiologic Studies-Depression Scale. Risk of diabetes over the 12-year follow-up period was assessed using Cox proportional hazard models with time-varying covariates.
RESULTS: After adjusting for covariates, both depressive symptoms [hazard ratio (HR): 1.06, 95% confidence interval (CI): 1.02-1.09] and psychiatric medication use (HR: 1.57, 95% CI: 1.25-1.96) were associated with development of diabetes. The interaction between depressive symptoms and medication use was significant (beta=-0.240, P=.049), indicating that the association between elevated depressive symptoms and diabetes was higher among respondents not taking medications. The associations between depressive symptoms and medication use were also attenuated by increasing body mass index.
CONCLUSION: Findings highlight the complex relationship between depressive symptoms and psychiatric medications on diabetes risk and the need for a nuanced understanding of these factors.
|User Guide Notes|
|Endnote Keywords|| |
Depression/Antidepressants/Type 2 diabetes/Longitudinal/Epidemiology
|Endnote ID|| |
|Alternate Journal||Gen Hosp Psychiatry|
|PubMed Central ID||PMC4558325|
|Grant List||R21-DK8356430 / DK / NIDDK NIH HHS / United States |
U01 AG009740 / AG / NIA NIH HHS / United States
F31 MH078443 / MH / NIMH NIH HHS / United States
K01-MH093642 / MH / NIMH NIH HHS / United States
R21 DK096375 / DK / NIDDK NIH HHS / United States
2P60MD002249-01 / MD / NIMHD NIH HHS / United States
K01 MH093642 / MH / NIMH NIH HHS / United States
U01AG009740 / AG / NIA NIH HHS / United States