|Title||Loneliness, eudaimonia, and the human conserved transcriptional response to adversity.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Cole, SW, Levine, ME, Arevalo, JMG, Ma, J, Weir, DR, Crimmins, EM|
|Date Published||2015 Dec|
|Keywords||Aged, Aged, 80 and over, Down-Regulation, Female, Humans, Inflammation, Loneliness, Longitudinal Studies, Male, Mental Health, Middle Aged, social isolation, Social Support, Stress, Psychological, Transcriptome|
BACKGROUND: Chronic social adversity activates a conserved transcriptional response to adversity (CTRA) marked by increased expression of pro-inflammatory genes and decreased expression of antiviral- and antibody-related genes. Recent findings suggest that some psychological resilience factors may help buffer CTRA activation, but the relative impact of resilience and adversity factors remains poorly understood. Here we examined the relative strength of CTRA association for the two best-established psychological correlates of CTRA gene expression-the risk factor of perceived social isolation (loneliness) and the resilience factor of eudaimonic well-being (purpose and meaning in life).
METHODS: Peripheral blood samples and validated measures of loneliness and eudaimonic well-being were analyzed in 108 community-dwelling older adults participating in the longitudinal US Health and Retirement Study (56% female, mean age 73). Mixed effect linear model analyses quantified the strength of association between CTRA gene expression and measures of loneliness and eudaimonic well-being in separate and joint analyses.
RESULTS: As in previous studies, separate analyses found CTRA gene expression to be up-regulated in association with loneliness and down-regulated in association with eudaimonic well-being. In joint analyses, effects of loneliness were completely abrogated whereas eudaimonic well-being continued to associate with CTRA down-regulation. Similar eudaimonia-dominant effects were observed for positive and negative affect, optimism and pessimism, and anxiety symptoms. All results were independent of demographic and behavioral health risk factors.
CONCLUSIONS: Eudaimonic well-being may have the potential to compensate for the adverse impact of loneliness on CTRA gene expression. Findings suggest a novel approach to targeting the health risks associated with social isolation by promoting purpose and meaning in life.
|User Guide Notes|
|Endnote Keywords|| |
Social genomics/Psychoneuroimmunology/Gene expression/Transcriptome/Microarray/Stress/Social support/Psychological well-being/Eudaimonia/Positive psychology
|Endnote ID|| |
|PubMed Central ID||PMC4637182|
|Grant List||R24 AG037898 / AG / NIA NIH HHS / United States |
R01 AG043404 / AG / NIA NIH HHS / United States
U01-AG009740 / AG / NIA NIH HHS / United States
R01 AG033590 / AG / NIA NIH HHS / United States
R24-AG037898 / AG / NIA NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States
T32 AG000037 / AG / NIA NIH HHS / United States
R37 AG033590 / AG / NIA NIH HHS / United States
P30 AG017265 / AG / NIA NIH HHS / United States
R01-AG033590 / AG / NIA NIH HHS / United States
P30-AG107265 / AG / NIA NIH HHS / United States