Comparative Genome-Wide Association Studies of a Depressive Symptom Phenotype in a Repeated Measures Setting By Race/Ethnicity in the Multi-Ethnic Study of Atherosclerosis

TitleComparative Genome-Wide Association Studies of a Depressive Symptom Phenotype in a Repeated Measures Setting By Race/Ethnicity in the Multi-Ethnic Study of Atherosclerosis
Publication TypeJournal Article
Year of Publication2015
AuthorsWare, EB, Mukherjee, B, Sun, YV, Diez-Roux, AV, Kardia, SLR
JournalBMC Genetics
Volume16
KeywordsDemographics, Health Conditions and Status, Women and Minorities
Abstract

Background: Time-varying phenotypes have been studied less frequently in the context of genome-wide analyses across ethnicities, particularly for mood disorders. This study uses genome-wide association studies of depressive symptoms in a longitudinal framework and across multiple ethnicities to find common variants for depressive symptoms. Ethnicity-specific GWAS for depressive symptoms were conducted using three approaches: a baseline measure, longitudinal measures averaged over time, and a repeated measures analysis. We then used meta-analysis to jointly analyze the results across ethnicities within the Multi-ethnic Study of Atherosclerosis (MESA, n = 6,335), and then within ethnicity, across MESA and a sample from the Health and Retirement Study African-and European-Americans (HRS, n = 10,163). Methods: This study uses genome-wide association studies of depressive symptoms in a longitudinal framework and across multiple ethnicities to find common variants for depressive symptoms. Ethnicity-specific GWAS for depressive symptoms were conducted using three approaches: a baseline measure, longitudinal measures averaged over time, and a repeated measures analysis. We then used meta-analysis to jointly analyze the results across ethnicities within the Multi-ethnic Study of Atherosclerosis (MESA, n = 6,335), and then within ethnicity, across MESA and a sample from the Health and Retirement Study African-and European-Americans (HRS, n = 10,163). Results: Several novel variants were identified at the genome-wide suggestive level (5x10(-8) p-value = 5x10(-6)) in each ethnicity for each approach to analyzing depressive symptoms. The repeated measures analyses resulted in typically smaller p-values and an increase in the number of single-nucleotide polymorphisms (SNP) reaching genome-wide suggestive level. Conclusions: For phenotypes that vary over time, the detection of genetic predictors may be enhanced by repeated measures analyses.

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DOI10.1186/s12863-015-0274-0
Endnote Keywords

ethnic differences/depressive Symptoms/Sociocultural Factors/African American

Endnote ID

999999

Citation Key8238
PubMed ID26459564
PubMed Central IDPMC4603946