Trajectories of body mass indices and development of frailty: Evidence from the health and retirement study.

TitleTrajectories of body mass indices and development of frailty: Evidence from the health and retirement study.
Publication TypeJournal Article
Year of Publication2016
AuthorsMezuk, B, Lohman, MC, Rock, AK, Payne, ME
JournalObesity (Silver Spring)
Date Published2016 08
ISSN Number1930-739X
KeywordsAged, Aged, 80 and over, Body Mass Index, Body Weight, Female, Frail Elderly, Geriatric Assessment, Health Status, Humans, Incidence, Longitudinal Studies, Male, Obesity, Retirement, Risk Factors, Weight Gain

OBJECTIVE: To estimate trajectories of body mass index (BMI) and determine their association with incident frailty in later life.

METHODS: Data come from the 2004 to 2012 waves of the Health and Retirement Study, a longitudinal survey of older adults. Analysis was restricted to respondents who were not frail at baseline (n = 10,827). BMI (kg/m(2) ) was calculated from self-reported weight and height. Incident frailty was assessed using the Frailty Index. Longitudinal growth mixture modeling was used to estimate the relationship between BMI trajectories and incident frailty over a 10-year period.

RESULTS: Four trajectory classes were identified: weight gain (n = 162 [1.4%], mean final BMI = 42 kg/m(2) ), weight loss (n = 171 [1.7%], mean final BMI = 25.0 kg/m(2) ), consistent obesity (n = 640 [6.8%], mean final BMI = 34.7 kg/m(2) ), and consistent overweight (n = 9,864 [90.1%] mean final BMI = 26.0 kg/m(2) ). Cumulative incidence of frailty was 19.9%. Relative to the consistent overweight class, the weight gain class had the highest likelihood of incident frailty (odds ratio, OR: 3.61, 95% confidence interval, CI: 2.39-5.46). The consistent obesity (OR: 2.72, 95% CI: 2.06-3.58) and weight loss (OR: 2.81, 95% CI: 1.84-4.30) classes had similarly elevated risk of frailty.

CONCLUSIONS: Weight change and obesity are associated with risk of frailty.

User Guide Notes

Alternate JournalObesity (Silver Spring)
Citation Key8510
PubMed ID27355440
PubMed Central IDPMC5433251
Grant ListK01 MH093642 / MH / NIMH NIH HHS / United States
K12 HD043446 / HD / NICHD NIH HHS / United States
P60 MD002249 / MD / NIMHD NIH HHS / United States
T32 MH073553 / MH / NIMH NIH HHS / United States