|Title||Motoric cognitive risk syndrome and risk of mortality in older adults.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Ayers, E, Verghese, J|
|Date Published||2016 05|
|Keywords||Age Factors, Aged, Cognition Disorders, Cohort Studies, Dementia, Early Diagnosis, Female, Gait, Humans, Male, Mortality, Risk Factors|
INTRODUCTION: Cognitive impairment is associated with increased mortality. We examined the association between motoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and cognitive complaints, and survival.
METHODS: A total of 11,867 nondemented participants aged >65 years from three established cohort studies in the United States and Europe were screened for MCR. Mortality risk of MCR was assessed with Cox and logistic regression models.
RESULTS: At baseline, 836 (7.0%) participants had MCR. Over a median follow-up of 28 months, 1603 participants died (758 in first 2 years). MCR was associated with increased mortality overall (adjusted hazard ratio, 1.69; 95% confidence interval [CI], 1.46-1.96) and 2-year mortality (adjusted odds ratio, 1.89; 95% CI, 1.50-2.38). The association remained after accounting for established mortality risk factors as well as baseline gait speed and memory performance.
DISCUSSION: MCR is associated with increased mortality. Older adults should be screened for MCR to identify at-risk individuals for dementia and death.
|User Guide Notes|
|Alternate Journal||Alzheimers Dement|
|Grant List||U01 AG009740 / AG / NIA NIH HHS / United States |
U01 AG032947 / AG / NIA NIH HHS / United States
P01 AG005842 / AG / NIA NIH HHS / United States
P01 AG008291 / AG / NIA NIH HHS / United States
P30 AG012815 / AG / NIA NIH HHS / United States
R21 AG025169 / AG / NIA NIH HHS / United States