Title | Late mortality after sepsis: propensity matched cohort study. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Prescott, HC, Osterholzer, JJ, Langa, KM, Angus, DC, Iwashyna, TJ |
Journal | BMJ |
Volume | 353 |
Pagination | i2375 |
Date Published | 2016 May 17 |
ISSN Number | 1756-1833 |
Keywords | Aged, Aged, 80 and over, Case-Control Studies, Cause of Death, Female, Hospital Mortality, Hospitalization, Humans, Longitudinal Studies, Male, Medicare, Propensity Score, Prospective Studies, Sepsis, Time Factors, United States |
Abstract | OBJECTIVES: To determine whether late mortality after sepsis is driven predominantly by pre-existing comorbid disease or is the result of sepsis itself. DEIGN: Observational cohort study. SETTING: US Health and Retirement Study. PARTICIPANTS: 960 patients aged ≥65 (1998-2010) with fee-for-service Medicare coverage who were admitted to hospital with sepsis. Patients were matched to 777 adults not currently in hospital, 788 patients admitted with non-sepsis infection, and 504 patients admitted with acute sterile inflammatory conditions. MAIN OUTCOME MEASURES: Late (31 days to two years) mortality and odds of death at various intervals. RESULTS: Sepsis was associated with a 22.1% (95% confidence interval 17.5% to 26.7%) absolute increase in late mortality relative to adults not in hospital, a 10.4% (5.4% to 15.4%) absolute increase relative to patients admitted with non-sepsis infection, and a 16.2% (10.2% to 22.2%) absolute increase relative to patients admitted with sterile inflammatory conditions (P<0.001 for each comparison). Mortality remained higher for at least two years relative to adults not in hospital. CONCLUSIONS: More than one in five patients who survives sepsis has a late death not explained by health status before sepsis. |
URL | https://www.ncbi.nlm.nih.gov/pubmed/27189000 |
DOI | 10.1136/bmj.i2375 |
User Guide Notes | |
Alternate Journal | BMJ |
Citation Key | 8547 |
PubMed ID | 27189000 |
PubMed Central ID | PMC4869794 |
Grant List | K08 GM115859 / GM / NIGMS NIH HHS / United States T32 HL007749 / HL / NHLBI NIH HHS / United States U01 AG009740 / AG / NIA NIH HHS / United States |