|Title||Late mortality after sepsis: propensity matched cohort study.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Prescott, HC, Osterholzer, JJ, Langa, KM, Angus, DC, Iwashyna, TJ|
|Date Published||2016 May 17|
|Keywords||Aged, Aged, 80 and over, Case-Control Studies, Cause of Death, Female, Hospital Mortality, Hospitalization, Humans, Longitudinal Studies, Male, Medicare, Propensity Score, Prospective Studies, Sepsis, Time Factors, United States|
OBJECTIVES: To determine whether late mortality after sepsis is driven predominantly by pre-existing comorbid disease or is the result of sepsis itself.
DEIGN: Observational cohort study.
SETTING: US Health and Retirement Study.
PARTICIPANTS: 960 patients aged ≥65 (1998-2010) with fee-for-service Medicare coverage who were admitted to hospital with sepsis. Patients were matched to 777 adults not currently in hospital, 788 patients admitted with non-sepsis infection, and 504 patients admitted with acute sterile inflammatory conditions.
MAIN OUTCOME MEASURES: Late (31 days to two years) mortality and odds of death at various intervals.
RESULTS: Sepsis was associated with a 22.1% (95% confidence interval 17.5% to 26.7%) absolute increase in late mortality relative to adults not in hospital, a 10.4% (5.4% to 15.4%) absolute increase relative to patients admitted with non-sepsis infection, and a 16.2% (10.2% to 22.2%) absolute increase relative to patients admitted with sterile inflammatory conditions (P<0.001 for each comparison). Mortality remained higher for at least two years relative to adults not in hospital.
CONCLUSIONS: More than one in five patients who survives sepsis has a late death not explained by health status before sepsis.
|User Guide Notes|
|PubMed Central ID||PMC4869794|
|Grant List||K08 GM115859 / GM / NIGMS NIH HHS / United States |
T32 HL007749 / HL / NHLBI NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States