|Title||Telomere Length Among Older U.S. Adults: Differences by Race/Ethnicity, Gender, and Age.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Brown, LL, Needham, BL, Ailshire, JA|
|Journal||J Aging Health|
|Date Published||2017 12|
|Keywords||Aged, Aging, Biomarkers, Female, Health Status Disparities, Humans, Interviews as Topic, Male, Minority Groups, Qualitative Research, Telomere, United States|
OBJECTIVE: We examine race/ethnic, gender, and age differences in telomere length (TL) within a diverse, nationally representative sample of older adults.
METHOD: Data come from 5,228 White, Black, and Hispanic respondents aged 54+ in the 2008 Health and Retirement Study. TL was assayed from saliva using quantitative polymerase chain reaction (qPCR) by comparing telomere sequence copy number with a single gene copy number (T/S ratio). Linear regression was used to examine TL by race/ethnicity, gender, and age adjusting for social, economic, and health characteristics.
RESULTS: Women had longer TL than men (p < .05). Blacks ( p < .05) and Hispanics ( p < .10) had longer TL than Whites. Black women and men had the longest TL relative to other groups ( p < .05), while White men had the shortest TL ( p < .05). Black women and Hispanic men showed greater differences in TL with age.
DISCUSSION: Findings indicate social patterns in TL by race/ethnicity, gender, and age among older adults do not reflect differences observed in most population health outcomes.
|User Guide Notes|
|Alternate Journal||J Aging Health|
|PubMed Central ID||PMC5272874|
|Grant List||P30 AG043073 / AG / NIA NIH HHS / United States |
R00 AG039528 / AG / NIA NIH HHS / United States
T32 AG000037 / AG / NIA NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States