Title | Validation of blood-based assays using dried blood spots for use in large population studies. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Crimmins, EM, Kim, JKi, McCreath, H, Faul, J, Weir, DR, Seeman, T |
Journal | Biodemography Soc Biol |
Volume | 60 |
Issue | 1 |
Pagination | 38-48 |
Date Published | 2014 |
ISSN Number | 1948-5573 |
Keywords | Biomarkers, C-reactive protein, Cholesterol, Cholesterol, HDL, Cystatin C, Dried Blood Spot Testing, Glycated Hemoglobin A, Humans, Middle Aged, Reference Values, Reproducibility of Results |
Abstract | Assessment of health in large population studies has increasingly incorporated measures of blood-based biomarkers based on the use of dried blood spots (DBS). The validity of DBS assessments made by labs used by large studies is addressed by comparing assay values from DBS collected using conditions similar to those used in the field with values from whole blood samples. The DBS approach generates values that are strongly related to whole blood levels of HbA1c, cystatin C, and C-reactive protein. Assessing lipid levels reliably with DBS appears to be a greater challenge. However, even when DBS values and values from venous blood are highly correlated, they are often on a different scale, and using conventional cutoffs may be misleading. |
URL | http://www.tandfonline.com/doi/abs/10.1080/19485565.2014.901885 |
DOI | 10.1080/19485565.2014.901885 |
User Guide Notes | |
Short Title | Biodemography and Social Biology |
Alternate Journal | Biodemography Soc Biol |
Citation Key | 8602 |
PubMed ID | 24784986 |
PubMed Central ID | PMC4117354 |
Grant List | P30 AG017265 / AG / NIA NIH HHS / United States R24 AG037898 / AG / NIA NIH HHS / United States U01 AG009740 / AG / NIA NIH HHS / United States P30 AG17265 / AG / NIA NIH HHS / United States |