Genomic assortative mating in marriages in the United States.

TitleGenomic assortative mating in marriages in the United States.
Publication TypeJournal Article
Year of Publication2014
AuthorsGuo, G, Wang, L, Liu, H, Randall, T
JournalPLoS One
Volume9
Issue11
Paginatione112322
Date Published2014
ISSN Number1932-6203
KeywordsGenetics, Marriage, Mating, Older Adults, Women and Minorities
Abstract

Assortative mating in phenotype in human marriages has been widely observed. Using genome-wide genotype data from the Framingham Heart study (FHS; number of married couples = 989) and Health Retirement Survey (HRS; number of married couples = 3,474), this study investigates genomic assortative mating in human marriages. Two types of genomic marital correlations are calculated. The first is a correlation specific to a single married couple "averaged" over all available autosomal single-nucleotide polymorphism (SNPs). In FHS, the average married-couple correlation is 0.0018 with p = 3 × 10(-5); in HRS, it is 0.0017 with p = 7.13 × 10(-13). The marital correlation among the positively assorting SNPs is 0.001 (p = .0043) in FHS and 0.015 (p = 1.66 × 10(-24)) in HRS. The sizes of these estimates in FHS and HRS are consistent with what are suggested by the distribution of the allelic combination. The study also estimated SNP-specific correlation "averaged" over all married couples. Suggestive evidence is reported. Future studies need to consider a more general form of genomic assortment, in which different allelic forms in homologous genes and non-homologous genes result in the same phenotype.

DOI10.1371/journal.pone.0112322
Alternate JournalPLoS ONE
Citation Key8609
PubMed ID25384046
PubMed Central IDPMC4226554
Grant ListRC1 DA029425-01 / DA / NIDA NIH HHS / United States