Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

TitleGenome-wide analysis identifies 12 loci influencing human reproductive behavior.
Publication TypeJournal Article
Year of Publication2016
AuthorsBarban, N, Jansen, R, de Vlaming, R, Vaez, A, Mandemakers, JJ, Tropf, FC, Shen, X, Wilson, JF, Chasman, DI, Nolte, IM, Tragante, V, van der Laan, SW, Perry, JRB, Kong, A, Ahluwalia, TS, Albrecht, E, Yerges-Armstrong, LM, Atzmon, G, Auro, K, Ayers, KL, Bakshi, A, Ben-Avraham, D, Berger, K, Bergman, A, Bertram, L, Bielak, LF, Bjornsdottir, G, Bonder, MJan, Broer, L, Bui, M, Barbieri, C, Cavadino, A, Chavarro, JE, Turman, C, Concas, MPina, Cordell, HJ, Davies, G, Eibich, P, Eriksson, N, Esko, T, Eriksson, J, Falahi, F, Felix, JF, Fontana, MAlan, Franke, LL, Gandin, I, Gaskins, AJ, Gieger, C, Gunderson, EP, Guo, X, Hayward, C, He, C, Hofer, E, Huang, H, Joshi, PK, Kanoni, S, Karlsson, R, Kiechl, S, Kifley, A, Kluttig, A, Kraft, P, Lagou, V, Lecoeur, C, Lahti, J, Li-Gao, R, Lind, PA, Liu, T, Makalic, E, Mamasoula, C, Matteson, LK, Mbarek, H, McArdle, PF, McMahon, G, S Meddens, FW, Mihailov, E, Miller, MB, Missmer, SA, Monnereau, C, van der Most, PJ, Myhre, R, Nalls, MA, Nutile, T, Kalafati, IPanagiota, Porcu, E, Prokopenko, I, Rajan, KB, Rich-Edwards, J, Rietveld, CA, Robino, A, Rose, LM, Rueedi, R, Ryan, KA, Saba, Y, Schmidt, D, Smith, JA, Stolk, L, Streeten, E, Tönjes, A, Thorleifsson, G, Ulivi, S, Wedenoja, J, Wellmann, J, Willeit, P, Yao, J, Yengo, L, Zhao, JHua, Zhao, W, Zhernakova, DV, Amin, N, Andrews, H, Balkau, B, Barzilai, N, Bergmann, S, Biino, G, Bisgaard, H, Bønnelykke, K, Boomsma, DI, Buring, JE, Campbell, H, Cappellani, S, Ciullo, M, Cox, SR, Cucca, F, Toniolo, D, Davey-Smith, G, Deary, IJ, Dedoussis, G, Deloukas, P, van Duijn, CM, de Geus, EJC, Eriksson, JG, Faul, JD, Sala, CFelicita, Froguel, P, Gasparini, PP, Girotto, GG, Grabe, H-J, Greiser, KHalina, Groenen, PJF, de Haan, HG, Haerting, J, Harris, TB, Heath, AC, Heikkilä, K, Hofman, A, Homuth, G, Holliday, EG, Hopper, JL, Hyppönen, E, Jacobsson, B, Jaddoe, V, Johannesson, M, Jugessur, A, Kähönen, M, Kajantie, E, Kardia, SLR, Keavney, B, Kolcic, I, Koponen, P, Kovacs, P, Kronenberg, F, Kutalik, Z, La Bianca, M, Lachance, G, Iacono, WG, Lai, S, Lehtimäki, T, Liewald, DC, Lindgren, CM, Liu, Y, Luben, R, Lucht, M, Luoto, R, Magnus, P, Magnusson, PKE, Martin, NG, McGue, M, McQuillan, R, Medland, SE, Meisinger, C, Mellström, D, Metspalu, A, Traglia, M, Milani, L, Mitchell, P, Montgomery, GW, Mook-Kanamori, DO, de Mutsert, R, Nohr, EA, Ohlsson, C, Olsen, J, Ong, KK, Paternoster, L, Pattie, A, Penninx, BWJH, Perola, M, Peyser, PA, Pirastu, M, Polasek, O, Power, C, Kaprio, J, Raffel, LJ, Räikkönen, K, Raitakari, OT, Ridker, PM, Ring, SM, Roll, K, Rudan, I, Ruggiero, D, Rujescu, D, Salomaa, V, Schlessinger, D, Schmidt, H, Schmidt, R, Schupf, N, Smit, J, Sorice, R, Spector, TD, Starr, JM, Stöckl, D, Strauch, K, Stumvoll, M, Swertz, MA, Thorsteinsdottir, U, A. Thurik, R, Timpson, NJ, Tung, JY, Uitterlinden, AG, Vaccargiu, S, Viikari, J, Vitart, V, Völzke, H, Vollenweider, P, Vuckovic, D, Waage, J, Wagner, GG, Wang, JJin, Wareham, NJ, Weir, DR, Willemsen, G, Willeit, J, Wright, AF, Zondervan, KT, Stefansson, K, Krueger, RF, Lee, JJ, Benjamin, DJ, Cesarini, D, Koellinger, PD, Hoed, Mden, Snieder, H, Mills, MC
Corporate AuthorsBIOS Consortium, LifeLines Cohort Study
JournalNat Genet
Volume48
Issue12
Pagination1462-1472
Date Published2016 Dec
ISSN Number1546-1718
Abstract

The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.

DOI10.1038/ng.3698
User Guide Notes

http://www.ncbi.nlm.nih.gov/pubmed/27798627?dopt=Abstract

Alternate JournalNat. Genet.
Citation Key8881
PubMed ID27798627
PubMed Central IDPMC5695684
Grant ListG1001799 / / Medical Research Council / United Kingdom
RG/15/12/31616 / / British Heart Foundation / United Kingdom
R01 AG051635 / AG / NIA NIH HHS / United States
MC_UU_12013/3 / / Medical Research Council / United Kingdom
SDR 10-012 / HX / HSRD VA / United States
Z99 AG999999 / / Intramural NIH HHS / United States
U01 AG016976 / AG / NIA NIH HHS / United States
MR/J012165/1 / / Medical Research Council / United Kingdom
UL1 TR000124 / TR / NCATS NIH HHS / United States
MR/K026992/1 / / Medical Research Council / United Kingdom
MC_PC_U127561128 / / Medical Research Council / United Kingdom
P30 AG038072 / AG / NIA NIH HHS / United States
P01 AG005842 / AG / NIA NIH HHS / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
/ / Wellcome Trust / United Kingdom
P30 AG012810 / AG / NIA NIH HHS / United States
R01 AG042568 / AG / NIA NIH HHS / United States
T32 AG000186 / AG / NIA NIH HHS / United States
615603 / / European Research Council / International
G9815508 / / Medical Research Council / United Kingdom
647648 / / European Research Council / International