Clinical Trials Targeting Aging and Age-Related Multimorbidity

TitleClinical Trials Targeting Aging and Age-Related Multimorbidity
Publication TypeJournal Article
Year of Publication2017
AuthorsEspeland, MA, Crimmins, EM, Grossardt, BR, Crandall, JP, Gelfond, JAL, Harris, TB, Kritchevsky, SB, Manson, JAE, Robinson, JG, Rocca, W, Temprosa, M, Thomas, F, Wallace, RB, Barzilai, N
JournalThe Journals of Gerontology Series A: Biological Sciences and Medical Sciences
ISSN Number1079-5006
KeywordsChronic disease, Clinical trials, Older Adults

There is growing interest in identifying interventions that may increase health span by targeting biological processes underlying aging. The design of efficient and rigorous clinical trials to assess these interventions requires careful consideration of eligibility criteria, outcomes, sample size, and monitoring plans.

Experienced geriatrics researchers and clinical trialists collaborated to provide advice on clinical trial design.

Outcomes based on the accumulation and incidence of age-related chronic diseases are attractive for clinical trials targeting aging. Accumulation and incidence rates of multimorbidity outcomes were developed by selecting at-risk subsets of individuals from three large cohort studies of older individuals. These provide representative benchmark data for decisions on eligibility, duration, and assessment protocols. Monitoring rules should be sensitive to targeting aging-related, rather than disease-specific, outcomes.

Clinical trials targeting aging are feasible, but require careful design consideration and monitoring rules.

Short TitleGERONA
Citation Key8936
PubMed ID28364543