|Title||Social Connectedness, Perceived Isolation, and Dementia: Does the Social Environment Moderate the Relationship Between Genetic Risk and Cognitive Well-Being?|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Poey, JL, Burr, JA, J Roberts, S|
|Date Published||2017 11 10|
|Keywords||Aged, Aged, 80 and over, Apolipoprotein E4, Cognition, Dementia, Female, Gene-Environment Interaction, Humans, Loneliness, Male, Residence Characteristics, Risk Factors, Social Environment, Social Perception, Social Support|
Purpose of the Study: This study examined whether the social environment moderates the relationship between the APOE e4 allele and cognitive functioning.
Design and Methods: The Aging, Demographics, and Memory Study (ADAMS) data and multinomial logistic regression models were used to investigate these relationships for a nationally representative sample of U.S. adults aged 70 and older (n = 779).
Results: Living alone (relative risk ratio [RRR] = 5.814; p = .000) and self-reported loneliness (RRR = 1.928, p = .049) were associated with a greater risk of cognitive difficulty. Living arrangements, perceived social support, and loneliness were found to moderate the relationship between the APOE e4 allele and cognitive function.
Implications: The results support the need to consider the social context when examining cognitive well-being in later life. These findings also indicate a need for the development of policies and services that promote a rich social environment.
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