Subjective Age and Cystatin C Among Older Adults.

TitleSubjective Age and Cystatin C Among Older Adults.
Publication TypeJournal Article
Year of Publication2019
AuthorsStephan, Y, Sutin, AR, Terracciano, A
JournalJ Gerontol B Psychol Sci Soc Sci
Volume74
Issue3
Pagination382-388
Date Published2019 02 15
ISSN Number1758-5368
KeywordsAged, 80 and over, Biomarkers, Cystatin C, depression, Female, Geriatric Assessment, Humans, Male, Middle Aged, Renal Insufficiency
Abstract

OBJECTIVE: Cystatin C (CysC) is a marker of kidney function that is relevant for the health and cognition of older adults. Little is known about the link between psychological factors and CysC. Therefore, the present study examined whether subjective age is related to CysC level and changes in CysC over time.

METHOD: Participants were 5,066 individuals drawn from the Health and Retirement Study aged from 50 to 107 years (60% women, mean age = 69.36 years, SD = 9.54). They provided data on subjective age, demographic covariates, and CysC at baseline. CysC was assessed again 4 years later.

RESULTS: Analysis revealed that an older subjective age was related to higher level of CysC at baseline and to an increase in CysC over 4 years, controlling for demographic factors. An older subjective age was also related to higher risk of exceeding the clinical threshold of CysC at baseline and 4 years later. Additional analysis revealed that disease burden, depressive symptoms, physical inactivity, and BMI partly mediated these associations.

CONCLUSION: The present study provides new evidence on the role of subjective age as a psychological factor associated with individuals' risk of kidney dysfunction, an association beyond chronological age.

DOI10.1093/geronb/gbx124
User Guide Notes

http://www.ncbi.nlm.nih.gov/pubmed/29045722?dopt=Abstract

Alternate JournalJ Gerontol B Psychol Sci Soc Sci
Citation Key9346
PubMed ID29045722
PubMed Central IDPMC6377033
Grant ListU01 AG009740 / AG / NIA NIH HHS / United States