Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies.

TitleGene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies.
Publication TypeJournal Article
Year of Publication2017
AuthorsZhao, W, Yasutake, K, August, C, Ratliff, SM, Faul, JD, Boerwinkle, E, Chakravarti, A, Diez-Roux, AV, Gao, Y, Griswold, ME, Heiss, G, Kardia, SLR, Morrison, AC, Musani, SK, Mwasongwe, S, North, KE, Rose, KM, Sims, M, Sun, YV, Weir, DR, Needham, BL
JournalInt J Environ Res Public Health
Volume14
Issue12
ISSN Number1660-4601
KeywordsBlood pressure, Genetics, GWAS, Meta-analyses, Psychosocial, Socioeconomic factors
Abstract

Inter-individual variability in blood pressure (BP) is influenced by both genetic and non-genetic factors including socioeconomic and psychosocial stressors. A deeper understanding of the gene-by-socioeconomic/psychosocial factor interactions on BP may help to identify individuals that are genetically susceptible to high BP in specific social contexts. In this study, we used a genomic region-based method for longitudinal analysis, Longitudinal Gene-Environment-Wide Interaction Studies (LGEWIS), to evaluate the effects of interactions between known socioeconomic/psychosocial and genetic risk factors on systolic and diastolic BP in four large epidemiologic cohorts of European and/or African ancestry. After correction for multiple testing, two interactions were significantly associated with diastolic BP. In European ancestry participants, outward/trait anger score had a significant interaction with the C10orf107 genomic region (p = 0.0019). In African ancestry participants, depressive symptom score had a significant interaction with the HFE genomic region (p = 0.0048). This study provides a foundation for using genomic region-based longitudinal analysis to identify subgroups of the population that may be at greater risk of elevated BP due to the combined influence of genetic and socioeconomic/psychosocial risk factors.

DOI10.3390/ijerph14121596
User Guide Notes

http://www.ncbi.nlm.nih.gov/pubmed/29258278?dopt=Abstract

Alternate JournalInt J Environ Res Public Health
Citation Key9429
PubMed ID29258278
PubMed Central IDPMC5751013
Grant ListR01 HL059367 / HL / NHLBI NIH HHS / United States
HHSN268201300048C / HL / NHLBI NIH HHS / United States
N01HC95168 / HL / NHLBI NIH HHS / United States
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R01 HL101161 / HL / NHLBI NIH HHS / United States
R03 AG046389 / AG / NIA NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States
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P60 MD002249 / MD / NIMHD NIH HHS / United States
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R01 HL086694 / HL / NHLBI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
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R01 MD011716 / MD / NIMHD NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201300049C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
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HHSN268201300047C / HL / NHLBI NIH HHS / United States
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HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HHSN268201300046C / HL / NHLBI NIH HHS / United States
UL1 TR000040 / TR / NCATS NIH HHS / United States
RC2 AG036495 / AG / NIA NIH HHS / United States
N01HC95166 / HL / NHLBI NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States