Title | Is Memory Decline Associated With Inflammatory Response? |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Tetlow, AM, Andel, R, Infurna, FJ |
Journal | Journal of Aging and Health |
Pagination | 898264317742809 |
ISSN Number | 1552-6887 |
Keywords | Biomarkers, Cognitive Ability, Inflammation, Memory |
Abstract | OBJECTIVE: To examine whether changes in memory over a 10-year period could predict a change in C-reactive protein (CRP) levels. METHOD: A mixed model analysis was first conducted to obtain the estimates for change in memory over the 10-year period using data from the Health and Retirement Study. Then a multivariate regression to determine whether a change in episodic memory could predict subsequent CRP levels was conducted. Furthermore, a general linear model was conducted to determine differences in CRP levels among different rates of change in episodic memory. RESULTS: Greater declines in episodic memory were associated with higher levels of subsequent CRP (Estimate = -0.32, SE = 0.12, β = -.03, p = .008). The general linear model revealed that those with greater memory declines were more likely to have higher levels of CRP, F = 26.50, p < .001. DISCUSSION: These results highlight the notion that memory decline and inflammation may be intertwined, and we discuss various avenues that warrant further investigation. |
DOI | 10.1177/0898264317742809 |
User Guide Notes | |
Alternate Journal | J Aging Health |
Citation Key | 9454 |
PubMed ID | 29254429 |