Is Memory Decline Associated With Inflammatory Response?

TitleIs Memory Decline Associated With Inflammatory Response?
Publication TypeJournal Article
Year of Publication2017
AuthorsTetlow, AM, Andel, R, Infurna, FJ
JournalJournal of Aging and Health
ISSN Number1552-6887
KeywordsBiomarkers, Cognitive Ability, Inflammation, Memory

OBJECTIVE: To examine whether changes in memory over a 10-year period could predict a change in C-reactive protein (CRP) levels.

METHOD: A mixed model analysis was first conducted to obtain the estimates for change in memory over the 10-year period using data from the Health and Retirement Study. Then a multivariate regression to determine whether a change in episodic memory could predict subsequent CRP levels was conducted. Furthermore, a general linear model was conducted to determine differences in CRP levels among different rates of change in episodic memory.

RESULTS: Greater declines in episodic memory were associated with higher levels of subsequent CRP (Estimate = -0.32, SE = 0.12, β = -.03, p = .008). The general linear model revealed that those with greater memory declines were more likely to have higher levels of CRP, F = 26.50, p < .001.

DISCUSSION: These results highlight the notion that memory decline and inflammation may be intertwined, and we discuss various avenues that warrant further investigation.

User Guide Notes

Alternate JournalJ Aging Health
Citation Key9454
PubMed ID29254429