The Effect of Adherence to Screening Guidelines on the Risk of Alzheimer's Disease in Elderly Individuals Newly Diagnosed With Type 2 Diabetes Mellitus.

TitleThe Effect of Adherence to Screening Guidelines on the Risk of Alzheimer's Disease in Elderly Individuals Newly Diagnosed With Type 2 Diabetes Mellitus.
Publication TypeJournal Article
Year of Publication2018
AuthorsYashkin, AP, Akushevich, I, Ukraintseva, S, Yashin, AI
JournalGerontology & Geriatric Medicine
Volume4
Pagination2333721418811201
Date Published2018 Jan-Dec
ISSN Number2333-7214
KeywordsAlzheimer's disease, Cognitive Ability, Diabetes, Medicare linkage, Screenings
Abstract

The aim of this study was to examine the possibility that type 2 diabetes and Alzheimer's disease may share common behavioral protective factors such as adherence to type 2 diabetes treatment guidelines given that these two diseases have both epidemiological and metabolic similarities. : The method used in this study is a retrospective cohort study of 3,797 U.S. Medicare fee-for-service beneficiaries aged 66+ newly diagnosed with type 2 diabetes and without a prior record of Alzheimer's disease based on the Health and Retirement Study. : Results of a left-truncated Cox model showed that adherence reduces the risk of Alzheimer's disease by 20% to 24%. Other significant effects were college education (hazard ratio [HR]: 0.65; value: .023), stroke (HR: 1.40; value: .013), and 4+ limitations in physical functioning (HR: 1.33; value: .008). : Risk of Alzheimer's disease can be reduced by behavioral factors. Possible mechanisms may include earlier start of interventions to reduce blood glucose levels and improve insulin sensitivity.

DOI10.1177/2333721418811201
User Guide Notes

http://www.ncbi.nlm.nih.gov/pubmed/30450369?dopt=Abstract

Alternate JournalGerontol Geriatr Med
Citation Key9930
PubMed ID30450369
PubMed Central IDPMC6236474
Grant ListP01 AG043352 / AG / NIA NIH HHS / United States
R01 AG046860 / AG / NIA NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States