Additive effects of obesity and loneliness on C-reactive protein.

TitleAdditive effects of obesity and loneliness on C-reactive protein.
Publication TypeJournal Article
Year of Publication2018
AuthorsPavela, G, Kim, Y-I, Salvy, S-J
JournalPLoS One
Date Published2018
ISSN Number1932-6203
KeywordsBiomarkers, BMI, C-reactive protein, Depressive symptoms, Loneliness

Obesity and loneliness are associated with C-reactive protein (CRP), a predictor of cardiovascular disease. It is unknown whether the co-presence of obesity and loneliness is associated with additional risk for clinically elevated CRP. The present study thus examines their independent and combined effects on elevated CRP in older adults. Data come from 10,912 respondents who completed the 2008 and 2010 waves of the Health and Retirement Study. Loneliness was measured using an 11-item Loneliness Scale and body mass index was calculated from technician measured height and weight. Our primary outcome is high sensitivity CRP (hsCRP). Survey-weighted logistic regression models were used to test whether loneliness and BMI category are independent predictors of CRP after adjusting for demographics and other inflammatory-related covariates. In the fully adjusted model for men, obesity (OR = 2.36, p < .0001) was associated with increased odds of hsCRP >3.0. Among females, being overweight (OR = 1.75, p < .0001) or obese (OR = 4.01, p < .0001) were associated increased odds of hsCRP>3.0. Among both men and women, results from fully adjusted models indicated that loneliness was not associated with clinically elevated hsCRP (OR = 1.34, p = .0535; OR = 0.97, p = 0.6776, respectively).

User Guide Notes

Alternate JournalPLoS ONE
Citation Key9938
PubMed ID30439985
PubMed Central IDPMC6237312
Grant ListP30 CA013148 / CA / NCI NIH HHS / United States